Pick Dodosend if…
Your mail is all Gmail
Thunderbird reaches Gmail over IMAP, so labels show up as folders, archiving removes the Inbox label, and Mozilla suggests hiding All Mail so messages don’t show up twice. Dodosend works with Gmail itself: labels stay labels, and from: or has:attachment work as they do in Gmail.
You’d rather not touch the mouse
Thunderbird has shortcuts, but no command palette, and changing them takes an add-on. In Dodosend every action has a key, ! shows the ones for the screen you’re on, and ⌘K (Ctrl+K) reaches the rest.
You want mail to come back when it matters
H brings a thread back at the time you type, and ⌘⇧H brings it back only if nobody replies. Scheduled send goes out on time even with the app closed.